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© 2008 Mirna Therapeutics
All Rights Reserved

Publications

Mirna Publications

• Esquela-Kerscher, A., P. Trang, J. F. Wiggins, L. Patrawala, A. Cheng, L. Ford, J. B. Weidhaas, D. Brown, A. G. Bader, and F. J. Slack.
  The let-7 microRNA reduces tumor growth in mouse models of lung cancer. 2008. Cell Cycle 7.


• Johnson, C. D., A. Esquela-Kerscher, G. Stefani, M. Byrom, K. Kelnar, D. Ovcharenko, M. Wilson, X. Wang, J. Shelton, J. Shingara, L. Chin, D. Brown, and F. J. Slack. 2007.
  The let-7 microRNA represses cell proliferation pathways in human cells. Cancer Res. 67:7713-22.


• Johnson, S. M., H. Grosshans, J. Shingara, M. Byrom, R. Jarvis, A. Cheng, E. Labourier, K. L. Reinert, D. Brown, and F. J. Slack. 2005.
  RAS is regulated by the let-7 microRNA family. Cell 120:635-47.


• Ovcharenko, D., K. Kelnar, C. Johnson, N. Leng, and D. Brown. 2007.
  Genome-scale microRNA and small interfering RNA screens identify small RNA modulators of TRAIL-induced apoptosis pathway. Cancer Res. 67:10782-8.


• Pappas T. C., A. G. Bader, B. F. Andruss, D. Brown, and L. P. Ford. 2008.
  Applying small RNA molecules to the directed treatment of human diseases: realizing the potential. Expert Opin Ther Targets. 12: 115-27.

Selected publications

• Akao, Y., Y. Nakagawa, and T. Naoe. 2006.
  MicroRNAs 143 and 145 are possible common onco-microRNAs in human cancers. Oncol Rep 16:845-50. Calin, G. A., C. Sevignani, C. D. Dumitru, T. Hyslop, E. Noch, S. Yendamuri, M. Shimizu, S. Rattan, F. Bullrich, M. Negrini, and C. M. Croce. 2004.


• Calin, G. A., C. Sevignani, C. D. Dumitru, T. Hyslop, E. Noch, S. Yendamuri, M. Shimizu, S. Rattan, F. Bullrich, M. Negrini, and C. M. Croce. 2004.
  Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci U S A 101:2999-3004.


• Chan, J. A., A. M. Krichevsky, and K. S. Kosik. 2005.
  MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Res 65:6029-33.


• Cimmino, A., G. A. Calin, M. Fabbri, M. V. Iorio, M. Ferracin, M. Shimizu, S. E. Wojcik, R. I. Aqeilan, S. Zupo, M. Dono, L. Rassenti, H. Alder, S. Volinia, C. G. Liu, T. J. Kipps, M. Negrini, and C. M. Croce. 2005. miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci U S A 102:13944-9.


• Costinean, S., N. Zanesi, Y. Pekarsky, E. Tili, S. Volinia, N. Heerema, and C. M. Croce. 2006.
  Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in E(mu)-miR155 transgenic mice. Proc Natl Acad Sci U S A 103:7024-9.


• Dews, M., A. Homayouni, D. Yu, D. Murphy, C. Sevignani, E. Wentzel, E. E. Furth, W. M. Lee, G. H. Enders, J. T. Mendell, and A. Thomas-Tikhonenko. 2006. Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster. Nat Genet 38:1060-5.


• Hayashita, Y., H. Osada, Y. Tatematsu, H. Yamada, K. Yanagisawa, S. Tomida, Y. Yatabe, K. Kawahara, Y. Sekido, and T. Takahashi. 2005.
  A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation. Cancer Res 65:9628-32.


• He, L., J. M. Thomson, M. T. Hemann, E. Hernando-Monge, D. Mu, S. Goodson, S. Powers, C. Cordon-Cardo, S. W. Lowe, G. J. Hannon, and S. M. Hammond. 2005.
  A microRNA polycistron as a potential human oncogene. Nature 435:828-33.


• He, L., X. He, L. P. Lim, E. de Stanchina, Z. Xuan, Y. Liang, W. Xue, L. Zender, J. Magnus, D. Ridzon, A. L. Jackson, P. S. Linsley, C. Chen, S. W. Lowe, M. A. Cleary, and G. J. Hannon. 2007.
  A microRNA component of the p53 tumour suppressor network. Nature 447:1130-4.


• Hossain, A., M. T. Kuo, and G. F. Saunders. 2006.
  Mir-17-5p regulates breast cancer cell proliferation by inhibiting translation of AIB1 mRNA. Mol Cell Biol 26:8191-201.


• Krutzfeldt, J., N. Rajewsky, R. Braich, K. G. Rajeev, T. Tuschl, M. Manoharan, and M. Stoffel. 2005. Silencing of microRNAs in vivo with 'antagomirs'. Nature 438:685-9.


• Kumar, M. S., S. J. Erkeland, R. E. Pester, C. Y. Chen, M. S. Ebert, P. A. Sharp, and T. Jacks. Suppression of non-small cell lung tumor development by the let-7 microRNA family. Proc Natl Acad Sci U S A 105:3903-8.


• Kumar M.S., J. Lu, K. L. Mercer, T. R. Golub, and T. Jacks. 2007.
  Impaired microRNA processing enhances cellular transformation and tumorigenesis. Nat Genet.39:673-7.


• Lu, J., G. Getz, E. A. Miska, E. Alvarez-Saavedra, J. Lamb, D. Peck, A. Sweet-Cordero, B. L. Ebert, R. H. Mak, A. A. Ferrando, J. R. Downing, T. Jacks, H. R. Horvitz, and T. R. Golub. 2005.
  MicroRNA expression profiles classify human cancers. Nature 435:834.


• Mayr, C., M. T. Hemann, and D. P. Bartel. 2007.
  Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation. Science 315:1576-9.


• Si, M. L., S. Zhu, H. Wu, Z. Lu, F. Wu, and Y. Y. Mo. 2007.
  miR-21-mediated tumor growth. Oncogene 26:2799-803.


• Tavazoie S.F., C. Alarcón, T. Oskarsson, D. Padua, Q. Wang, P. D. Bos, W. L. Gerald, and J. Massagué J. 2008.
  Endogenous human microRNAs that suppress breast cancer metastasis. Nature 451:147-52.


• Volinia, S., G. A. Calin, C. G. Liu, S. Ambs, A. Cimmino, F. Petrocca, R. Visone, M. Iorio, C. Roldo, M. Ferracin, R. L. Prueitt, N. Yanaihara, G. Lanza, A. Scarpa, A. Vecchione, M. Negrini, C. C. Harris, and C. M. Croce. 2006.
  A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci U S A 103:2257-61.


• Voorhoeve, P. M., C. le Sage, M. Schrier, A. J. Gillis, H. Stoop, R. Nagel, Y. P. Liu, J. van Duijse, J. Drost, A. Griekspoor, E. Zlotorynski, N. Yabuta, G. De Vita, H. Nojima, L. H. Looijenga, and R. Agami. 2006. A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. Cell 124:1169-81


• Weidhaas, J. B., I. Babar, S. M. Nallur, P. Trang, S. Roush, M. Boehm, E. Gillespie, and F. J. Slack. 2007. MicroRNAs as potential agents to alter resistance to cytotoxic anticancer therapy. Cancer Res.67:11111-6.


• Welch, C., Y. Chen, and R. L. Stallings. 2007.
  MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells. Oncogene 26:5017-22.


• Yanaihara, N., N. Caplen, E. Bowman, M. Seike, K. Kumamoto, M. Yi, R. M. Stephens, A. Okamoto, J. Yokota, T. Tanaka, G. A. Calin, C. G. Liu, C. M. Croce, and C. C. Harris. 2006.
  Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell 9:189-98.


• Yu, F., H. Yao, P. Zhu, X. Zhang, W. Pan, C. Gong, Y. Huang, S. Hu, F. Su, J. Lieberman, and E. Song. let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell 131:1109-23.

Review articles

• Calin, G. A., and C. M. Croce. 2006.
  MicroRNA signatures in human cancers. Nat Rev Cancer 6:857-66.


• Esquela-Kerscher, A., and F. J. Slack. 2006.
  Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer 6:259-69.


• Garzon, R., M. Fabbri, A. Cimmino, G. A. Calin, and C. M. Croce. 2006.
  MicroRNA expression and function in cancer. Trends Mol Med 12:580-7.


• Perron, M. P., V. Boissonneault, L. A. Gobeil, D. L. Ouellet, and P. Provost. 2007.
  Regulatory RNAs: future perspectives in diagnosis, prognosis, and individualized therapy. Methods Mol Biol 361:311-26.


• Qi, P., J. X. Han, Y. Q. Lu, C. Wang, and F. F. Bu. 2006.
  Virus-encoded microRNAs: future therapeutic targets? Cell Mol Immunol 3:411-9


• Slack, F. J., and J. B. Weidhaas. 2006.
  MicroRNAs as a potential magic bullet in cancer. Future Oncol 2:73-82


• Wurdinger, T., and F. F. Costa. 2006.
  Molecular therapy in the microRNA era. Pharmacogenomics J 2007 Oct 7 (5):297-304.


• Zhang, B., X. Pan, G. P. Cobb, and T. A. Anderson. 2007.
  microRNAs as oncogenes and tumor suppressors. Dev Biol 302:1-12.